Cases of neurofibromatosis type 1 (NF1)-associated medullary thyroid carcinoma (MTC) or C-cell hyperplasia are rarely associated with other endocrine tumors or cases with a multiple endocrine neoplasia type 2.In these patients, mutations read more were detected in the NF1 gene but no mutations were detected in the RET gene.Although vandetanib has been shown to improve progression-free survival in adults with advanced canine spectra kc 3 intranasal single dose MTC, data in pediatric patients are limited.
Herein, we report the use and outcome of vandetanib in a pediatric MTC case in which NF1 gene and RET proto-oncogen mutation were identified together.